Current issues in reproductive and developmental toxicology

can an international guideline be achieved
  • 181 Pages
  • 3.66 MB
  • 4168 Downloads
  • English

Quay , Lancaster
Drugs -- Physiological effect., Genetic toxicology., Reproduction -- Effect of drug
Statementedited by Cyndy E. Lumley and Stuart R. Walker.
SeriesCMR workshop series
ContributionsLumley, C. E., Walker, Stuart R., 1944-
Classifications
LC ClassificationsRA1224.3. C87 1991
The Physical Object
Paginationxv, 181 p. :
ID Numbers
Open LibraryOL20255569M
ISBN 101856420736

Reproductive and developmental toxicology is a very complex subject because of continuous changes taking place in the mother, placenta and the unborn. Developing organisms are more sensitive than adults to the toxic effects of chemicals because of limited defense and detoxifying mechanisms.

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each.

Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential.

The in vivo assessments included here are guideline-driven and are. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of.

The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology.

Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition.

Weissinger J (d) The regulations and Current issues in reproductive and developmental toxicology book underlying concepts and philosophy — the USA perspective. In: Lumley C and Walker S (eds) Current Issues in Reproductive and Developmental Toxicology, Proc Workshop held at Ciba Foundation, London, MayQuay Publ, pp Author: Judi Weissinger.

All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival.

Adverse reproductive effects.

Description Current issues in reproductive and developmental toxicology EPUB

This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et al., ).Author: HESI.

Reproductive and Developmental Toxicology 1st Edition. by Kenneth S. Korach (Author) ISBN ISBN Why is ISBN important.

ISBN. Current issues in reproductive and developmental toxicology book This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Author: Kenneth S. Korach. Developmental and reproductive toxicology is a complex and important subset of the science of toxicology.

The consequences of even some minor missteps during the reproductive process and/or the biology of the developing gamete/fetus can have devastating consequences to the very survival of that : Robert W. Kapp. CiteScore: ℹ CiteScore: CiteScore measures the average citations received per document published in this title.

CiteScore values are based on citation counts in a given year (e.g. ) to documents published in three previous calendar years (e.g. – 14), divided by the number of documents in these three previous years (e.g. – 14). The ultimate goal of all toxicology research is to utilize reliable and predictive toxicity testing to understand and prevent exposure to potentially harmful toxicants of reproducing animals and humans as well as developing individuals.

This Special Issue focuses on reproductive and developmental toxicology. This book, Reproductive and Developmental Toxicology, provides the most intricate and comprehensive overview of both historical and current knowledge of reproductive and developmental toxicology.

The book is divided into 15 sections that address various aspects of this field of toxicology. The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment.

In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including. Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource.

In addition to the traditional aspects of developmental toxicity testing, the book covers eCited by: Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives.

Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental : Hardcover. Reproductive and Developmental Toxicology book. DOI link for Reproductive and Developmental Toxicology.

Reproductive and Developmental Toxicology book. By Kenneth S. Korach and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of by: Book Description.

The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment.

In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment.

Reproductive and Developmental Toxicology Maternal Mediated Toxicity Assessment of Reproductive and Developmental. Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components-parent, placenta, and fetus-and the continuous changes that occur in each.

Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated. Principles of Toxicology. Toxicology studies the injurious effects of chemical and physical agents on living organisms, observed as alterations in structure and covered includes:Targets and Bio-Transformation, Toxicokinetics, Hemato- and Vascular Toxicity, Dermatotoxicity, Neurotoxicity, Hepatotoxicity, Nephrotoxicity, Pulmonary Toxicity, Reproductive Toxicity, Geno toxicity.

Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food Manufacturer: Academic Press.

Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food Format: NOOK Book (Ebook).

Scope. To encourage the development of the field of reproductive and developmental toxicology, this research section welcomes interdisciplinary research, ranging from material and chemical science, exposure assessment, epidemiology, in vitro and experimental animal science, basic and molecular biology, in silico modeling, and risk assessment.

Get this from a library. Reproductive and developmental toxicology. [Ramesh C Gupta;] -- Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each.

Reproductive and Developmental Toxicology is. Part of the Current Issues in Toxicology book series (CI TOXICOLOGY) Abstract Assessment of human reproductive risk from developmental toxicity data involves three steps: (1) conducting animal and, if possible, human studies; (2) evaluating these data; and (3) using these data in the extrapolation of reproductive risk to : K.

Khera, H. Grice, D.

Details Current issues in reproductive and developmental toxicology PDF

Clegg. Previous books, with the exception of the Handbook of Developmental Toxicology, the current book’s predecessor, have largely been “academically oriented” and not intended to guide the practicing developmental or reproductive sely, the book is useful as well as informative.

It provides insights gained from hands-on experience, in addition to a theoretical foundation. We conduct male and female fertility, developmental toxicity (embryo-fetal development), pre- and postnatal development and multigenerational studies, (including OECDthe Extended One Generation Reproductive Toxicity Study, (EOGRTS)), to assess the potential effects of novel products on the entire reproductive spectrum.

Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science.

It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food Book Edition: 1. Editorial Reviews.

Download Current issues in reproductive and developmental toxicology FB2

Reviewer: Robert S. Egerman, MD (University of Tennessee at Memphis College of Medicine) Description: This multiauthored text addresses the effects of environmental agents on fertility and the developing conceptus.

It is divided into segments, beginning with developmental effects and neurotoxicity, followed by the effects on female and male :. Developmental and Reproduction Toxicology—A Practical Approach, Second Edition Article (PDF Available) in International Journal of Toxicology 26(1) January with ReadsAuthor: Robert Kapp.Exponent is unique in that we can bring to bear powerful multi-disciplinary expertise in industrial hygiene, epidemiology, toxicology, and risk assessment on solving scientific problems in developmental and reproductive toxicology and human health risk assessment.

Related Publications. DeSesso, JM, Williams AL, Ahuja A, Bowman CJ, Hurtt ME.Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each.